Membrane Pharmacy Structure Dynamics
Research group : Priv.Doz. Dr. Thomas Nawroth
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Teaching "BioAnalytics - Biophysical and Biochemical methods" at TUM-Weihenstephan - Freising
- (9.-2002) At the Bio-Science Center WZW, Freising, which is a part of the Technical University Munich, I teach Biophysics.for biologists at the WZW-Physics Institute (E14, Prof. J.Friedrich). In the Winter semester 2002/2003 a lecture "Bioanalytics - Biophysical Anlytics" is given. This includes the analytical characterization of proteins, nucleic acids, membranes and lipids by biophysical and biochemical methods. The lecture follows in part th book "Bioanalytik" of Lottspeich (Spektrum Verlag).
Teaching Biophysics for Biologists-2 "Basics of Structural Biology" at TUM-Weihenstephan - Freising
- (4.-2002) At the Bio-Science Center WZW, Freising, which is a part of the Technical University Munich, I teach Biophysics.for biologists at the WZW-Physics Institute (E14, Prof. J.Friedrich). In the Summer semester 2002 a lecture "Biophysics for Biologists 2" is given. This includes: Structural biology: spectroscopy (absorption, fluorescence), labeling, radiation biophysics, basics of : Mößbauer spectroscopy, X-ray absorption, X-ray scattering, Neutron scattering (solutions; SAXS, SANS)
Scientific Equipment of MPSD transfered to TUM
- (7-10.-2001) After long discussions, I got my scientific equipment, which was obtained by my science funding (BMBF, DFG), from Mainz to Munich-Garching. Thus the MPSD project becomes now fully operative again in protein purification (HPLC, FPLC), time resolved scattering (SAXS, SANS), chemical synthesis and model membranes.
Teaching Biophysics for Biologists-1 at TUM-Weihenstephan - Freising
- (6.-2001) At the Bio-Science Center WZW, Freising, which is a part of the Technical University Munich, I start teaching Biophysics.for biologists at the WZW-Physics Institute (E14, Prof. J.Friedrich). In the Wintersemester 2001/2002 a lecture "Biophysics for Biologists 1" is given. This includes: Cells, membranes, transport accross membranes, potentials, basics of spectroscopy (absorption, fluorescence), model membranes (monolayers, BLM, liposomes), electron microscopy, microscopy techniques, labeling, FRAP
MPSD change to Munich TUM Physics-E17
- (1.4.-2001) After retirement of the former leader of the Biochemistry institute at Mainz, Prof. Dose, I changed for research and teaching to the technical university Munich TUM, Physics-Department-E17 (Lehrstuhl Prof. Parak, Garching). At Garching I manage the Biochemistry and Genetics, related to structure dynamics research at the E17-division. As far as possible, the MPSD research is continued as my project at the E17-division (Lehrstuhl). The teaching of membrane biochemistry and biophyscal chemistry at Mainz is continued (Monday morning in the semester). The bioenergetics research at Mainz is continued as a cooperation with apl.Prof. H.-J- Schaefer.
Updates of MPSD pages
- (5.12-2000) The following pages have been updated: "technnology" and "time resolved methods"
- (11.2000) The structural film of molecular motions in working ATP-Synthase/F1ATPase obtained with time resolved X-ray scattering (TR-SAXS) is has been updated. The data and figures from direct experiments are complete. The multishot-(auto)correlation and modelling follows after completion. Look at the topic AS-Film.
Structural biology scientific network
(20.5.2000) As a cooperation of several groups a scientific network for structur research of biological systems is under development. As the suggestion of the corresponding theme #2 in the german BMBF structure research funding funding programme, the network is organized by T. Nawroth, Gutenberg-University Mainz, and R. Willumeit, GKSS, Geesthacht. Special announcements of the funding programme are presented by the BMBF-BEO divisions at DESY.HS and at FZ-Jülich. While anybody is free to apply for funding as he think it is useul, the proposed network is a collaboration of groups experienced in structural biology with common interests and technology. The network shall cover tight cooperations and sharing of equipment and resources, e.g. common beam time applications/ cooperation- experiments and long term projects (DESY/HASYLAB, ESRF, ELETTRA, ILL etc.). Those collaborations have already been established. e.g. in the study group "structure dynamics of flexible protein domains". The proposed new network is organized in three topics, each covering about 8 projects (status 19.5.2000), which are organized by the given representatives:
"Structural biology - molecular motion and molecular complexes" (BioDynamics) email to: BioMotion@MPSD.de
Topic A : "Molecular motion" (time resolved synchrotron X-ray and neutron structure investigations); organizer: T. Nawroth, Gutenberg-University Mainz
Topic B : "Molecular complexes" (contrast techniques with neutrons and synchrotron X-ray radiation); organizer: R. Willumeit, GKSS, Geesthacht
Topic C : "Intermediate states in biological processes" (EXAFS / XAS synchrotron X-ray studies); organizer: G. Henkel, Mercator-University, Duisburg
Activities: In phase1 (current) short project proposals are collected and organized. In phase2 (mid June) a project leader meeting shall be organized for preparation of the final applications. In phase3 (July) the common network application with project short descriptions (1 page text + 1 page data) shall be submitted to the BMBF-BEO divisions; in parallel the project shall submit their special project application.
(4.12.2000) As a consequence of the extremely low amount of money available for structural biology the funding rate in the above BMBF-BEO field has droped down to about 25% ! Thus